ʻO ka lōʻihi o nā 'hoods' pale i ka hopena o nā chromosomes (DNA), nā telomeres, hiki ke hoʻoholo i ka hopena o ka make mai Covid i nā wahine. Ua ʻike ʻia e ka noiʻi i hana ʻia ma Carlos III Health Institute i hōʻike ʻia ma ka European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), e hōʻike ana i nā telomeres pōkole, kahi hiʻohiʻona o ka ʻelemakule, hiki ke hoʻololi i ka paʻakikī o Covid -19. a me ka pilikia o ka make ʻana i ka maʻi, ʻoi aku ka nui o nā wahine.
"Ua ʻike mākou i ka pōkole o nā telomeres, ʻoi aku ka nui o nā wahine ma luna o 65 mau makahiki, he hopena ia i ka hopena o ka make, e hoʻonui ana," wahi a Ana Virseda-Berdices, Amanda Fernández-Rodríguez a me M.
ʻO Ángeles Jiménez-Sousa, nā mea kākau o ka hana.
"Ke hōʻike nei kā mākou ʻike i ka hana o ka telomere lōʻihi i ka make mai Covid-19 a hōʻike i kona hiki ke wānana i ka make a me nā maʻi koʻikoʻi, ʻoi aku hoʻi i nā wahine kahiko," wahi a Virseda Berdices.
"Ke noʻonoʻo nei mākou - ʻōlelo lākou - hiki ke lilo i mea hōʻailona pono i ke keʻena kino".
Hoʻopōkole nā Telomeres i ke ola. Hoʻohana pinepine ʻia kona lōʻihi e like me ke ana o ka makahiki cell. Hoʻopili ʻia nā telomeres pōkole me nā maʻi e pili ana i ka makahiki, e like me ka maʻi kanesa a me ka osteoarthritis, a me ka piʻi nui ʻana o ka hoʻomohala ʻana i nā maʻi.
E noʻonoʻo i ka lōʻihi o ka telomere he hōʻailona pono i loko o ke keʻena
Ma waho aʻe o ka ʻelemakule, wehewehe ʻo Virseda Berdices, "ua pili pū ʻia ka telomere dysfunction me ka puhi ʻana, ka ʻai maikaʻi ʻole, ke kiʻekiʻe kiʻekiʻe o ke kino nui a me nā mea ʻē aʻe e makemake nui ai i ke koʻikoʻi oxidative, ʻeha mau a me ka maʻi kanesa."
Hāʻawi ʻia i ke koʻikoʻi o ka lōʻihi o ka telomere i ke olakino cellular a me ka ʻelemakule, he mea nui ia e hoʻomaopopo i ka dinamika telomere i ka maʻi Covid-19.
Ua hōʻoia nā mea kākau i ka lōʻihi o ka telomere i aʻo ʻia i nā maʻi like ʻole, e like me ka cardiovascular -coronary heart disease or atherosclerosis-, type II diabetes, cerebrovascular accident, a me ka nui o ka pilikia o nā maʻi, a ua ʻike kekahi mau noiʻi "he ka hui ma waena o ka lōʻihi o ka telomere pōkole a me ka piʻi ʻana o ka pilikia o ka hoʻokipa ma muli o ka maʻi.
Ma kēia noiʻi ʻana, ua loiloi mākou i ka pilina ma waena o ka lōʻihi telomere pili (RTL) i ka hoʻomaka ʻana o ka hoʻopaʻa ʻia a me ka make mai Covid-19 ma 608 mau mākua hānai me Covid-19 i ka nalu mua o ka maʻi maʻi (Malaki a Kepakemapa 2020). .
E ʻike ʻia ka pepehi kanaka koko i loko o 20 mau lā o ka maʻi maʻi a i ʻole ka hale hoʻokipa o Covid-19. Eia kekahi, ua hana ʻia ka loiloi genetic me PCR no ke ana ʻana i ka lōʻihi o nā telomeres i loko o ke koko.
He nui nā ʻano hana e ana i nā telomeres, wehewehe ʻo ia, a ʻo PCR, i kēia lā, "hiki i ka hiki ʻana o kekahi haukapila."
Ua helu nā mea noiʻi i nā mea hiki ke ola a ua hoʻohana i nā hiʻohiʻona e ʻimi i ka hui ma waena o ka lōʻihi o ka telomere pili a me ka make, me ka noʻonoʻo ʻana i nā ʻano maʻi e like me ka makahiki, ke kāne, ka ulaula, a me nā maʻi pili.
ʻO ka loaʻa ʻana o ka lōʻihi telomere pili i pili me ka 70% haʻahaʻa haʻahaʻa o ka make mai Covid-19 i nā wahine āpau i 30 mau lā, a me 76% i 90 mau lā.
ʻO nā mea maʻi i komo i ka hoʻokolokolo, 533 i ola (mean makahiki 67 makahiki, 58% kāne, 73% keʻokeʻo, 24% Hispanic) a me 75 i make mai Covid-19 (mean makahiki 78 makahiki, 67% kāne, 77% keʻokeʻo). a me 21% Paniolo).
Ua ʻike ʻia ka loiloi i nā mea maʻi āpau, pili ka lōʻihi o ka telomere pili me ke ʻano nui me ka make mai Covid-19 no 30 a me 90 mau lā ma hope o ka hoʻokipa ʻana. Ma nā huaʻōlelo ʻē aʻe, wehewehe lākou, ʻo ia hoʻi, ʻo ka loaʻa ʻana o nā telomeres pōkole e pili ana i ka piʻi ʻana o ka make a me nā telomeres lōʻihi me ka hōʻemi ʻana i ka hopena o ka make.
I ka wā i nānā ʻia ai ka ʻikepili e ka makahiki a me ke kāne, ua ʻike nā mea noiʻi ʻo ka loaʻa ʻana o ka lōʻihi telomere pili i pili me ka 70% haʻahaʻa haʻahaʻa o ka make mai Covid-19 i nā wahine āpau i 30 mau lā, a me 76% i 90 mau lā.
Pēlā nō, ʻo ka noiʻi ʻana i nā wahine ma luna o 65 mau makahiki, ʻoi aku ka lōʻihi o ka telomere pili me ka 78% haʻahaʻa haʻahaʻa o ka make mai Covid-19 ma 30 mau lā a me 81% haʻahaʻa i nā lā 90.
Eia nō naʻe, ʻaʻole mākou e ʻike i nā ʻokoʻa koʻikoʻi i ka lōʻihi o nā telomeres ma waena o nā kāne i ola iā Covid-19 a me ka poʻe i make i kumu hoʻopaʻa ʻia.
Hoʻomaopopo nā mea kākau he haʻawina nānā ʻana kēia a ʻaʻole hōʻoia i ke kumu a me ka hopena, a ʻo ia hoʻi, i ka wā o ka nalu mua o ka maʻi maʻi, hiki ke kaupalena i nā hopena i hiki ke huki ʻia.
Ma kēia hihia, kuhikuhi ʻo Virseda Berdices, ʻoiai ʻaʻole mākou i ʻike i ke kumu o ka hui ikaika i loaʻa i nā wahine, "hiki ke ʻike ʻia ka ʻole o ka hui ʻana ma waena o ka lōʻihi o nā telomeres a me ka make mai Covid-19 i nā kāne ke kūkākūkā ʻia i ka ka piʻi ʻana o nā comorbidities a me nā kumu pilikia i loko o kēia mau mea i uhi i ka hopena.
No ka mea, ua hoʻohui ʻo ia, ʻoi aku ka liʻiliʻi o ka maʻi maʻi a, no laila, "ʻoi aku ka nui o ke ola ʻana iā Ovid-19, ma muli paha o ka liʻiliʻi o nā kumu pilikia a me nā ʻano o ka nohona ma mua o nā kāne."
