Uphononongo lwamazwe ngamazwe olukhokelwa ngabaphandi beCSIC lufumene indlela entsha elawula ukusebenza kweeseli ze-stem kwingqondo kwaye ikhuthaza i-neurogenesis (isizukulwana se-neurons entsha) ebomini bonke.
Umsebenzi, oye waba kuqweqwe lwephephancwadi "IiNgxelo zeSeli", ubonisa ukubaluleka kokuphulaphula izitshixo zofuzo ezize zikhuthaze i-neurogenesis yabantu abadala kwaye ivule umnyango woyilo lwemimandla yengqondo, i-neuron entsha iqhubeka isenza ubomi bonke. Isitshixo silele kwiiseli ze-neural stem, ezinokuthi zivelise ii-neuron ezintsha.
Nangona kunjalo, ezi seli zihlala zilele. Yingakho umsebenzi okhokelwa ngu-Aixa V. Morales, umphandi kwi-Cajal Institute yeCSIC
, ufumana ukubaluleka okukhulu. Ichazile iiproteni ezithile, ezikhoyo kwiiseli ze-stem, eziyimfuneko ekusebenzeni kwe-neurogenesis yabantu abadala.
Iqela liye lafumanisa ukuba iiprotheni ze-Sox5 kunye ne-Sox6 zifumaneka ikakhulu kwiiseli ze-neural stem ze-hippocampus, ezinoxanduva lokukhumbula kunye nokufunda.
Iqela lifumanise ukuba iiproteni ze-Sox5 kunye ne-Sox6 zifumaneka ikakhulu kwiiseli ze-neural stem ze-hippocampus, ezinoxanduva lokukhumbula kunye nokufunda.
"Sisebenzise iindlela zofuzo ezisivumela ukuba sikhethe ukukhetha ezi proteni kwiiseli zengqondo yeempuku zabantu abadala kwaye sibonise ukuba zibalulekile ekusebenzeni kwezi seli kunye nokuveliswa kwee-neuron ezintsha kwi-hippocampus", ucacise u-Aixa. V. Morales.
Kulo msebenzi, iqela, apho amaqela ka-Helena Mira, kwi-Institute of Biomedicine yaseValencia (IBV-CSIC) kunye noCarlos Vicario, ovela kwiCajal Institute, nabo baye bancedisa, baye baqaphela ukuba utshintsho luthintela iigundane. ngokutyebisa kokusingqongileyo (izithuba ezibanzi nezintsha) zinokuvelisa ii-neuron ezintsha.
"Phantsi kweemeko ezifanelekileyo, kukho ukusebenza okukhulu kweeseli ze-stem kwaye, ke ngoko, inani elikhulu lee-neurons liya kuveliswa. Nangona kunjalo, ukupheliswa kwe-Sox5 kwingqondo yezimpuku ngumqobo kwi-neurogenesis ”, utshilo uMorales.
Ngaphaya koko, olunye uphononongo lubonise ukuba iSox5 kunye ne-Sox6 utshintsho ebantwini lubangela izifo ezinqabileyo ze-neurodevelopmental, ezifana ne-Lamb-Shaffer kunye ne-Tolchin-Le Caignec syndromes. Ezi zinto zibangela ukusilela kwengqondo kunye nemikhondo ye-autism spectrum.
"Lo msebenzi uya kuvumela ukuqonda okungcono kweenguqu ezibalulekileyo ze-neuronal ezibonakaliswa ekuvaleni," uphetha uMorales.
