Phuputso ea machaba e etelletsoeng pele ke bafuputsi ba CSIC e fumane mokhoa o mocha o laolang ts'ebetso ea lisele tsa stem bokong le tse khothalletsang neurogenesis (moloko oa li-neurone tse ncha) bophelong bohle.
Mosebetsi, o 'nileng oa sekoahelo sa makasine ea "Cell Reports", e bontša bohlokoa ba ho mamela linotlolo tsa liphatsa tsa lefutso tse bileng li khothalletsang neurogenesis ea batho ba baholo le ho bula monyako oa moralo oa libaka tsa boko, li-neurone tse ncha li tsoela pele ho theha bophelo bohle. Senotlolo se ka har'a lisele tsa neural stem, tse nang le monyetla oa ho hlahisa li-neuron tse ncha.
Leha ho le joalo, hangata lisele tsena li lula li robetse. Ke ka lebaka leo mosebetsi o etelletsoeng ke Aixa V. Morales, mofuputsi oa Cajal Institute ea CSIC
, e fumana bohlokoa bo boholo. Ho eona, liprotheine tse ling, tse teng liseleng tsa stem, tse bohlokoa bakeng sa ts'ebetso ea neurogenesis ea batho ba baholo li hlalositsoe.
Sehlopha se sibolotse hore liprotheine tsa Sox5 le Sox6 li fumanoa haholo-holo liseleng tsa neural stem tsa hippocampus, tse ikarabellang bakeng sa ho hopola le ho ithuta.
Sehlopha se sibolotse hore liprotheine tsa Sox5 le Sox6 li fumanoa haholo-holo liseleng tsa neural stem tsa hippocampus, tse ikarabellang bakeng sa ho hopola le ho ithuta.
"Re sebelisitse mekhoa ea liphatsa tsa lefutso e re lumellang hore re khetholle liprotheine tsena liseleng tsa boko ba litoeba tse hōlileng 'me re bontšitse hore li bohlokoa bakeng sa ts'ebetsong ea lisele tsena le bakeng sa ho hlahisa li-neurone tse ncha hippocampus", a hlalosa Aixa. V. Morales.
Mosebetsing ona, sehlopha, moo lihlopha tsa Helena Mira, tse tsoang Setsing sa Biomedicine ea Valencia (IBV-CSIC) le Carlos Vicario, oa Cajal Institute, le tsona li thusitseng, le tsona li hlokometse hore liphetoho li thibela litoeba. ka matlafatso ea tikoloho (libaka tse pharaletseng le tse ncha) li ka hlahisa li-neurone tse ncha.
"Tlas'a maemo a matle, ho na le ts'ebetso e kholo ea lisele tsa stem, ka hona, ho tla hlahisoa palo e kholo ea li-neuron. Leha ho le joalo, ho felisoa ha Sox5 bokong ba litoeba tsena ke tšitiso bakeng sa neurogenesis ”, ho boletse Morales.
Ho feta moo, liphuputso tse ling li bontšitse hore liphetoho tsa Sox5 le Sox6 bathong li baka mafu a sa tloaelehang a neurodevelopmental, a kang Lamb-Shaffer le Tolchin-Le Caignec syndromes. Tsena li baka bofokoli ba kelello le mesaletsa ea autism spectrum.
"Mosebetsi ona o tla lumella kutloisiso e betere ea liphetoho tsa bohlokoa tsa methapo ea kutlo tse hlahang litlamong," ho phethela Morales.
