Tsawon 'mafi' masu kariya a ƙarshen chromosomes (DNA), telomeres, na iya ƙayyade haɗarin mutuwa daga Covid a cikin mata. An gani ta hanyar binciken da aka gudanar a Cibiyar Kiwon Lafiya ta Carlos III wanda aka gabatar a Majalisar Tarayyar Turai na Clinical Microbiology and Diseases (ECCMID), wanda ke ba da shawarar cewa gajeriyar telomeres, halayyar tsufa, na iya yin tasiri ga tsananin Covid-19. da kuma hadarin mutuwa daga cutar, musamman ga mata.
"Mun lura cewa rage telomeres, musamman a cikin mata fiye da shekaru 65, yana da tasiri kan hadarin mutuwa, yana karuwa," in ji Ana Virseda-Berdices, Amanda Fernández-Rodríguez da M.
Ángeles Jiménez-Sousa, marubutan aikin.
"Bincikenmu ya nuna rawar telomere a cikin mace-mace daga Covid-19 kuma yana nuna yuwuwar sa a matsayin mai hasashen mutuwa da rashin lafiya, musamman a cikin tsofaffin mata," in ji Virseda Berdices.
"Mun yi la'akari - sun ce - cewa zai iya zama alamar amfani a asibitin".
Telomeres yana rage tsawon rayuwa. Yawancin lokaci ana amfani da tsawonsa azaman ma'aunin shekarun tantanin halitta. Ƙananan telomeres suna da alaƙa da yawancin cututtukan da suka shafi shekaru, ciki har da ciwon daji da osteoarthritis, da kuma ƙara haɗarin kamuwa da cututtuka.
Yi la'akari da cewa tsayin telomere na iya zama alamar amfani a asibitin
Bugu da ƙari, tsufa, in ji Virseda Berdices, "ƙananan telomere kuma yana da alaƙa da shan taba, rashin abinci mara kyau, mafi girman nauyin jiki da sauran abubuwan da suka fi dacewa da damuwa na oxidative, kumburi na kullum da kuma ciwon daji."
Ganin mahimmancin tsayin telomere a lafiyar salula da tsufa, yana da mahimmanci a fahimci motsin telomere a cikin kamuwa da cuta na Covid-19.
Marubutan sun ba da tabbacin cewa an yi nazarin tsawon telomere a cikin cututtuka daban-daban, irin su cututtukan zuciya -coronary heart disease ko atherosclerosis-, nau'in ciwon sukari na II, hadarin cerebrovascular, da kuma haɗarin kamuwa da cuta, kuma wasu bincike sun gani " dangantaka tsakanin guntun telomere da ƙara haɗarin asibiti saboda kamuwa da cuta."
A cikin wannan binciken, mun yi nazarin ƙungiyar tsakanin dangin telomere tsawon (RTL) a farkon tsarewa da mace-mace daga Covid-19 a cikin manya 608 da ke asibiti tare da Covid-19 a lokacin farkon bala'in cutar (Maris zuwa Satumba 2020). .
Za a gane kisan kai na jini a cikin kwanaki 20 na ganewar asali ko asibiti na Covid-19. Bugu da ƙari, an yi nazarin kwayoyin halitta tare da PCR don auna tsawon telomeres a cikin kwayoyin jini.
Akwai dabaru da yawa don auna telomeres, in ji shi, kuma PCR, a yau, "yana cikin isa ga kowane asibiti."
Masu binciken sun ƙididdige yiwuwar rayuwa kuma sun yi amfani da samfura don bincika haɗin gwiwa tsakanin dangi telomere tsawon rayuwa da mace-mace, la'akari da halaye masu haƙuri kamar shekaru, jinsi, shan taba, da cututtuka masu alaƙa.
Samun tsayin telomere na dangi yana da alaƙa da ƙarancin 70% na haɗarin mutuwa daga Covid-19 a cikin duka mata a cikin kwanaki 30, da 76% a cikin kwanaki 90.
Daga cikin marasa lafiyar da aka haɗa a cikin binciken, 533 sun tsira (yana nufin shekaru 67, 58% maza, 73% farare, 24% Hispanic) da 75 sun mutu daga Covid-19 (yana nufin shekaru 78, 67% maza, 77% farare). kuma 21% Mutanen Espanya).
Binciken ya gano cewa a cikin duk marasa lafiya, tsayin telomere na dangi yana da alaƙa da mahimmiyar mahimmanci tare da mutuwa daga Covid-19 na kwanaki 30 da 90 bayan an kwantar da su a asibiti. A wasu kalmomi, sun bayyana, yana nufin cewa samun guntun telomeres yana da alaƙa da haɗarin mutuwa da kuma tsayin telomeres tare da raguwa a cikin haɗarin mutuwa.
Lokacin da aka bincikar bayanan ta shekaru da jinsi, masu binciken sun gano cewa samun tsayin telomere na dangi yana da alaƙa da ƙarancin 70% na haɗarin mutuwa daga Covid-19 a cikin duk mata a cikin kwanaki 30, da 76% a cikin kwanaki 90.
Hakanan, binciken cewa a cikin mata sama da shekaru 65, tsayin telomere dangi yana da alaƙa da ƙarancin haɗarin mutuwa daga 78% daga Covid-19 a cikin kwanaki 30 da 81% ƙasa a cikin kwanaki 90.
Koyaya, ba za mu sami bambance-bambance masu yawa a cikin kusancin tsawon telomeres tsakanin mutanen da suka tsira daga Covid-19 da waɗanda suka mutu suna haifar da ɗauri.
Marubutan sun yarda cewa wannan bincike ne na lura kuma baya tabbatar da dalili da sakamako kuma, ƙari ga haka, a lokacin bullar cutar ta farko, wannan na iya iyakance yanke shawarar da za a iya zana.
A wannan yanayin, Virseda Berdices ya nuna, kodayake ba mu san dalilan da ke haifar da ƙaƙƙarfan ƙungiyar da aka samu a cikin mata ba, "yana yiwuwa rashin haɗin gwiwa tsakanin tsayin telomeres da mace-mace daga Covid-19 a cikin maza ana tattaunawa da su. haɓakar cututtuka da abubuwan haɗari a cikin waɗannan waɗanda suka rufe tasirin.
Domin, ya kara da cewa, marasa lafiya na iya samun rashin lafiya mai tsanani kuma, sabili da haka, "ya fi dacewa su tsira daga Ovid-19, mai yiwuwa saboda ƙananan abubuwan haɗari da kuma salon rayuwa fiye da maza."
