Chidzidzo chepasirese chinotungamirwa nevatsvaguri veCSIC chakawana nzira nyowani inodzora kuvhurwa kwemasero muuropi uye inosimudzira neurogenesis (chizvarwa chenyuroni) muhupenyu hwese.
Basa, iro rave riri pabutiro remagazini "Cell Reports", rinoratidza kukosha kwekuteerera makiyi emajini ayo anotokurudzira akura neurogenesis uye anovhura musuwo wekugadzirwa kwenharaunda dzehuropi, neuroni hutsva hunoramba huchiumbwa muhupenyu hwese. Kiyi iri mumaneural stem masero, ane mukana wekugadzira neurons itsva.
Zvisinei, kazhinji masero aya anoramba akarara. Ndicho chikonzero basa rinotungamirirwa naAixa V. Morales, muongorori paCajal Institute yeCSIC
, inowana kukosha kukuru. Mariri, mamwe mapuroteni, aripo mumasero emasero, anokosha pakushandiswa kwevakuru neurogenesis akatsanangurwa.
Iri boka rakaona kuti mapuroteni eSox5 neSox6 anowanikwa zvakanyanya mumaseru neural stem eiyo hippocampus, ane basa rekurangarira nekudzidza.
Boka rakaona kuti mapuroteni eSox5 neSox6 anowanikwa kunyanya mumaseru neural stem ehippocampus, ane basa rekurangarira nekudzidza.
"Takashandisa nzira dzemajini dzinotitendera kuti tibvise mapuroteni aya kubva muuropi stem masero embeva dzakura uye takaratidza kuti akakosha pakuita kuti maseru aya ashande uye pakugadzirwa kwemaneuroni matsva muhippocampus", akatsanangura Aixa. V. Morales.
Mubasa iri, boka, umo mapoka aHelena Mira, kubva kuInstitute of Biomedicine yeValencia (IBV-CSIC) naCarlos Vicario, kubva kuCajal Institute, vakabatsirawo, vakaonawo kuti kuchinja kunodzivirira mbeva kubva. nekupfumisa kwezvakatipoteredza (nzvimbo dzakafara uye itsva) vanogona kugadzira neuroni itsva.
"Pasi pemamiriro ezvinhu akanaka, kune kushanya kwakakura kweiyo stem maseru uye, nekudaro, nhamba huru yemaneuron ichagadzirwa. Nekudaro, kubviswa kweSox5 kubva muuropi hwembeva idzi chipingamupinyi kune neurogenesis ”, akadaro Morales.
Uyezve, zvimwe zvidzidzo zvakaratidza kuti Sox5 uye Sox6 kuchinja muvanhu kunokonzera zvisingawanzoitiki neurodevelopmental zvirwere, zvakadai seGwayana-Shaffer uye Tolchin-Le Caignec syndromes. Izvi zvinokonzeresa kushomeka kwenjere uye kurongeka kweiyo autism spectrum.
"Iri basa rinobvumira kunzwisisa kuri nani kweakakosha neuronal shanduko inoratidzwa muhusungwa," anopedzisa Morales.
