Vanhu vakaremara nekushandisa cocaine vanoratidza shanduko mukutaura kwemajini munzvimbo mbiri dzehuropi: nucleus accumbens, dunhu rakabatana nemubairo, uye caudate nucleus, dunhu rinoyananisa kuumbwa kwetsika.
Izvi zvakaonekwa mutsvakurudzo yakaitwa paIcahn School of Medicine paGomo reSinai uye yakabudiswa mu "Science Advances" ichirayira kuti kuchinja uku, uko kunobatsira zvikuru kune kuenderera mberi kwehutsika husina kunaka hunoonekwa mukupindwa muropa nezvinodhaka, zvinogadzirwa nekushandisa cocaine zvakakonzera mutsara wemakemikari. maitiro anotungamira mukuwedzera kwehuwandu hwenhume RNA iyo inogadzirwa kubva kune mamwe magene akakanganisika munzvimbo idzi mbiri dzehuropi, nepo basa remamwe majini richiderera.
Kurasikirwa muhuwandu hwemutumwa RNA inogadzirwa, maitiro anozivikanwawo se "kutaura" kweiyo majini ari pasi, anotungamira kune shanduko muhuwandu hwemapuroteni anogadzirwa ipapo anozoita maitiro emakemikari muuropi, vaongorori vanotsanangura mubasa rake.
Chikwata ichi chakawana kupindirana kwakakosha pakati peRNAs inoratidzwa munharaunda ino yehuropi, zvichiratidza kuti shanduko idzi dzemamorekuru dzinogona kuve kiyi mukusimudzira nekuchengetedza cocaine kushandisa kusagadzikana.
Chirwere chekushandisa cocaine chirwere chisingaperi, chinodzokororwa muuropi icho pari zvino pasina marapiro anotenderwa. Zvakare zvinofungidzirwa kuti kudzorwa kweiyo gene kutaura muuropi yekukurudzira uye mubairo nzvimbo inobata basa rakakosha mukuenderera mberi kwekuchinja kwehunhu kunotsanangura kupindwa muropa, ruzivo runoramba rusina kudzikamisa iyo maladaptive gene chiitiko icho chisingaperi kushandiswa kwecocaine kunokonzera mumatunhu aya muvanhu. uye kuti inokonzera kukanganisa nekushandisa cocaine.
Kugadzirisa gaka reruzivo, timu yakaita kutevedzana kweRNA pane ese ari maviri nucleus accumbens uye caudate nucleus yepostmortem uropi tishu kubva kuvanhu vane cocaine kushandisa kusagadzikana uye madhiraivha anowirirana. Tichishandisa iro rakakura uye rakasiyana cohort rakaongororwa kusvika parizvino, takaona kuti shanduko muurouroinflammatory process.
Cocaine inowedzera huwandu hweiyo neurotransmitter dopamine pamasynapses, kana makutano pakati pemasero europi ayo masaini emagetsi anoshandurwa kuita zviratidzo zvemakemikari. Mukuita izvi, kokeini inoburitsa kutevedzana kwezviitiko izvo zvinomisikidza kemikari mutumwa muuropi inonzi AMP kutenderera, izvo zvinozotungamira kune shanduko mukutaura kwemajini.
"Pamusoro peruzivo rutsva rwekuchinja kwemamolecular kunoshandiswa necocaine, takaona kuti vanhu vane chirwere chekushandisa cocaine vane dysregulated majini ane hukama neschizophrenia uye kuora mwoyo kukuru, zvichiratidza kuti kusagadzikana uku kunogona kugovera mamwe masisitimu eeuroni, maseketi uye zvigadziriso zvepasi. majini”, anodaro Philipp Mews, munyori wekutanga wechinyorwa ichi.
Mhedzisiro yacho inomiririra kubudirira mukunzwisisa kwema molecular abnormalities mune cocaine kushandisa kusagadzikana.
Nekuti zvakaoma kudzidza zvakananga kuti zvinodhaka senge cocaine zvinoitika sei kuhuropi hwemunhu, vaongorori vanowanzo shandisa mhando dzemhuka kudzidza mhedzisiro yavo. Zvisinei, mubvunzo unokosha ndewekuti izvo mhuka idzi dzinodzidza zvakafanana nezvinoitika muuropi hwevanhu vanoshandisa cocaine.
"Chikwata chedu chakaongorora zvidzidzo zvakaitwa mumakonzo kuti zvidzidze nezve nguva yekuzvitonga kwecocaine uye kuenzanisa mhedzisiro yekuchinja kwema molecular nekucherechedzwa mu postmortem brain tissue kubva kune vanhu vane cocaine kushandisa chirwere. Ongororo iyi yakaratidza kushanduka kwakafanana kwakafanana muuropi gene expression profiles mumakonzo uye vanhu, zvichisimbisa kushandiswa kwemakonzo kudzidza nezve physiological hwaro hwekushandisa cocaine kusagadzikana, "akatsanangura Eric J. Nestler, munyori anotungamira.
Izvi zvakawanikwa, ivo vanonyora, zvinomiririra kufambira mberi kukuru mukunzwisisa kwedu kwema molecular abnormalities mukushandisa cocaine kusagadzikana uye kubata chinhu chakakosha chekutsvaga mune ramangwana.
