Ua ʻike ʻia kahi noiʻi honua i alakaʻi ʻia e nā mea noiʻi CSIC i kahi hana hou e hoʻomalu ai i ka hoʻōla ʻana o nā pūnaewele i loko o ka lolo a hoʻoikaika i ka neurogenesis (hanauna o nā neurons hou) i ke ola.
ʻO ka hana, aia ma ka uhi o ka puke "Cell Reports", e hōʻike ana i ke koʻikoʻi o ka hoʻolohe ʻana i nā kī genetic e hoʻoikaika i ka neurogenesis makua a wehe i ka puka i ka hoʻolālā ʻana o nā ʻāpana lolo, hoʻomau nā neurons hou i ke ola a pau. Aia ke kī i loko o nā neural stem cell, kahi hiki ke hana i nā neurons hou.
Eia naʻe, maʻa mau kēia mau pūnaewele. ʻO ia ke kumu o ka hana i alakaʻi ʻia e Aixa V. Morales, ka mea noiʻi ma ka Cajal Institute o ka CSIC
, loaʻa ka pilina nui. I loko o ia mea, ua wehewehe ʻia kekahi mau protein, aia i loko o nā cell stem, pono no ka hoʻāla ʻana o ka neurogenesis makua.
Ua ʻike ka hui i loaʻa nā protein Sox5 a me Sox6 i loko o nā neural stem cell o ka hippocampus, kuleana no ka hoʻomanaʻo a me ke aʻo ʻana.
Ua ʻike ka hui i loaʻa nā protein Sox5 a me Sox6 i loko o nā pūnaewele neural stem o ka hippocampus, kuleana no ka hoʻomanaʻo a me ke aʻo ʻana.
"Ua hoʻohana mākou i nā hoʻolālā genetic e hiki ai iā mākou ke hoʻopau i kēia mau protein mai ka lolo o nā ʻiole makua a ua hōʻike mākou he mea nui ia no ka hoʻāla ʻana o kēia mau cell a no ka hana ʻana o nā neurons hou i ka hippocampus", wehewehe ʻo Aixa. V. Morales.
Ma kēia hana, ua kōkua pū ka hui, kahi o nā hui o Helena Mira, mai ka Institute of Biomedicine of Valencia (IBV-CSIC) a me Carlos Vicario, mai ka Cajal Institute, ua ʻike pū i ka pale ʻana i nā ʻiole. me ka hoʻonui ʻana i ke kaiapuni (nā ākea ākea a hou aku) hiki iā lākou ke hana i nā neurons hou.
"Ma lalo o nā kūlana maikaʻi, ʻoi aku ka nui o ka hoʻoulu ʻana o nā pūnaewele a no laila, e hoʻonui ʻia ka nui o nā neurons. Eia nō naʻe, ʻo ka hoʻopau ʻana o Sox5 mai ka lolo o kēia mau ʻiole he mea keakea ia no ka neurogenesis ", wahi a Morales.
Eia kekahi, ua hōʻike ʻia nā haʻawina ʻē aʻe ʻo ka hoʻololi ʻana o Sox5 a me Sox6 i ke kanaka ke kumu i nā maʻi neurodevelopmental kakaikahi, e like me Lamb-Shaffer a me Tolchin-Le Caignec syndromes. Hoʻokumu kēia i nā hemahema cognitive a me nā ʻano o ka spectrum autism.
"E ʻae kēia hana i ka hoʻomaopopo maikaʻi ʻana i nā loli neuronal koʻikoʻi i hōʻike ʻia i loko o ka hoʻopaʻa ʻana," hoʻopau ʻo Morales.
