Bvudzi rakachena riri mufashoni, asi havasi vose vanofarira kuzviratidzira uye vazhinji vanorota imwe mhinduro yekuidzosera iyo hazvirevi kuti inofanira kuidhayira nguva nenguva. Tsvagiridzo nyowani, yakaburitswa mujenari 'Nature', yakaratidza zvakadzama maitiro ari kukonzeresa bvudzi. Kuwanikwa mumakonzo izvo, kubva mukusimbiswa muvanhu, jasi remusuwo rine mukana wekurapa kudzorera bvudzi kune inozivikanwa ruvara rwechisikigo.
Zvinoenderana nemhedzisiro yeongororo yakasarudzika, mamwe ma stem cell anokwanisa kufamba pakati pezvikamu zvekukura mumafollicle ebvudzi, asi nekungomira nyore kuyerera uye kurasikirwa nekukwanisa kukura uye kuchengetedza ruvara rwebvudzi sezvavanochembera.
Inotungamirirwa nevatsvakurudzi veNew York University Grossman Chikoro cheMishonga, basa idzva rakatarisa kune rudzi rweganda reganda mumakonzo, rinowanikwawo muganda revanhu, rinonzi melanocyte stem masero, kana McSC. Iwe uri kutungamira kuvandudza yako melanocytes, sezvo iwe uchinyanya kugadzira melanin uye yakakosha kune ruvara rweganda rako.
Chidzidzo chitsva ichi chakaratidza kuti maMcSC anoumbwa zvinoshamisa, zvichireva kuti panguva yekukura kwebvudzi, maseru akadaro anogara achifamba achidzokera kumashure paaxis yekukura sezvaanofamba pakati pezvikamu zvebvudzi riri kukura.
Mukutaura kwechokwadi, timu yekutsvagisa yakaona kuti iyo McSC morphed pakati peiyo primitive cell nhanho uye yekupedzisira nhanho yekukura kwayo, nhanho yekukwidziridzwa uye kutsamira kwenzvimbo.
Sezvo bvudzi richichembera, rinodonha, uye richibva rakura richidzoka, nhamba dzinowedzera dzeMcSC dzinova 'dzakanamatira' mu stem cell compartment inonzi hair follicle bulge. Ikoko ivo vanozosara, vasingakure kumamiriro ekufambisa uye kusadzokera kunzvimbo yekutanga mukamuri yegerminal, vachipa mapuroteni eWNT ayo angadai akasunda kuti aitezve mumasero epigment.
"Chidzidzo chedu chinowedzera kunzwisiso yedu yekutanga yekuti melanocyte stem masero anoshanda sei kugadzira bvudzi. Idzi nzira dzichangowanikwa dzinosimudza mukana wekuti imwechete melanocyte stem cell process inogona kunge iripo muvanhu. Kana zvakadaro, inopa nzira inogona kudzoreredza kana kudzivirira kuchembera kwebvudzi revanhu nekubatsira maseru akanamira kumashure pakati pezvikamu zvebvudzi riri kukura," akatsanangura kudaro mukuru weongororo iyi, Qi Sun, a postdoctoral paNYU. Langone Health.
Vatsvakurudzi vanoti plasticity yeMcSC haipo mune mamwe masero, akadai seaya anoumba bvudzi rebvudzi pacharo, iro rinozivikanwa kuti rinoshandura nenzira imwe chete pamusoro penguva yakatarwa sezvainokura. izvo zvinosimudzira mafambiro hazvidzokeri kune yavo yekutanga stem cell state. Izvi zvinobatsira kutsanangura muchidimbu chikonzero nei bvudzi richigona kuramba richikura kunyange kana pigmentation yaro ikakundikana, anowedzera Zuva.
Pakutanga basa rakaitwa nechikwata chimwe chete chekutsvagisa cheNYU chakaratidza kuti kusaina kweWNT kwaive kwakakosha kukurudzira maMcSC kuti akure uye abudise pigment.
Mukuyedzwa kwazvino mumakonzo ane vhudzi rachembera ne epilation uye kumanikidzwa kukura, huwandu hwebvudzi follicles neMcSCs dzakanamira mufollicle pons dzakawedzera kubva pa15% pamberi pepilation kusvika inenge hafu mushure mekumanikidzwa kuchembera. Masero aya haakwanisi kudzoreredza kana kukura kuita pigment-inogadzira melanocyte. Vakarega hunhu hwavo hwekuvandudza nekuti vaive vasisaonekwi neWNT kusaina kwakawanda, uye nekudaro kugona kwavo kugadzira pigment mumafollicles ebvudzi matsva, ayo airamba achikura, akakanganiswa.
Kusiyana neizvi, iyo McSC yakaramba ichifamba ichidzoka pakati pefollicle bulge uye utachiona hwebvudzi yakaramba ichikwanisa kuvandudza, kukura kuita melanocytes, uye kugadzira pigment mukati memakore maviri ekudzidza.
"Iko kurasikirwa kwechameleon basa mu melanocyte stem masero anogona kukonzera kuchembera uye kurasikirwa kwebvudzi ruvara. Izvi zvakawanikwa zvakaratidza kuti melanocyte stem cell motility uye kudzokororwa kusiyanisa ndizvo zvakakosha pakuchengetedza hutano, bvudzi rine mavara, "akadaro muongorori mukuru wezvidzidzo Mayumi Ito, Ronald O. Perelman Purofesa weDermatology uye Dhipatimendi reCell Biology paNYU Langone Health.
Chikwata chine hurongwa hwekuferefeta nzira dzekudzoreredza motility yeMcSCs kana sezviri pachena kuvadzosera kunzvimbo yavo yeutachiona, kwavanogona kugadzira pigment.
