Cov kws kho mob tau tshaj tawm tias tib neeg yuav tsum sim zam kom tsis txhob noj effervescent acetaminophen uas yaj hauv ntsev, nrog rau cov txiaj ntsig ntawm kev tshawb fawb txuas nws mus rau kev pheej hmoo siab ntawm plawv nres, mob stroke, plawv nres thiab tuag.
Kev tshawb fawb ntawm qee tus neeg mob 300.000 sau npe nrog UK thawj kws kho mob tau luam tawm hauv European Heart Journal.
Sodium, ib qho tseem ceeb ntawm cov ntsev, yog siv los pab cov tshuaj xws li acetaminophen yaj thiab tawg hauv dej.
Txawm li cas los xij, effervescent thiab soluble formulations ntawm 0,5 g paracetamol ntsiav tshuaj yuav muaj 0,44 thiab 0,39 g ntawm sodium, feem. Yog hais tias ib tug neeg muaj qhov siab tshaj plaws koob tshuaj ntawm 0,5 g compressed koob tshuaj txhua txhua 3,5 teev, noj 3,1 thiab 2 g ntawm sodium feem, ib koob tshuaj uas ntau tshaj tag nrho cov kev noj txhua hnub ntawm XNUMX g pom zoo los ntawm World Health Organization. Muaj lwm cov formulations uas muaj ib qho me me ntawm sodium los yog tsis muaj hlo li.
Kev noj ntsev ntau dhau tau paub tias yog qhov teeb meem loj rau pej xeem kev noj qab haus huv thiab cuam tshuam nrog kev pheej hmoo ntawm cov hlab plawv thiab kev tuag ntawm cov neeg mob ntshav siab. Txawm li cas los xij, muaj cov pov thawj tsis sib xws ntawm qhov kev pheej hmoo zoo sib xws rau cov neeg muaj ntshav siab thiab nws yuav ua tsis ncaj ncees los sim ua kom muaj kev tswj hwm los ntsuas qhov no.
Cov kws tshawb fawb, coj los ntawm xibfwb Chao Zeng los ntawm Xiangya Tsev Kho Mob, Central South University hauv Changsha, Tuam Tshoj, tau tshuaj xyuas cov ntaub ntawv los ntawm UK Health Network, uas yog cov ntaub ntawv kho mob hluav taws xob ntawm kwv yees li 17 lab cov ntaub ntawv kho mob.
4.532 cov neeg mob ntshav siab uas tau txais paracetamol uas muaj sodium tau kuaj thiab piv nrog 146.866 cov neeg mob ntshav siab uas tau txais paracetamol yam tsis muaj sodium.
Nws kuj tau muab piv rau 5.351 cov neeg mob uas tsis muaj ntshav siab thaum lawv tau txais paracetamol uas muaj sodium nrog 141.948 cov neeg mob uas tsis muaj ntshav siab thaum lawv tau txais paracetamol yam tsis muaj sodium. Cov neeg mob muaj hnub nyoog ntawm 60 thiab 90 xyoo, thiab cov kws tshawb fawb tau ua raws lawv rau ib xyoos.
Cov kws tshawb fawb pom tau tias ib xyoos muaj kev pheej hmoo ntawm plawv nres, mob stroke, lossis lub plawv tsis ua haujlwm rau cov neeg mob ntshav siab noj sodium-muaj acetaminophen tee yog 5,6% (122 CVD), thaum nws yog 4,6% (3051 CVD mob) ntawm cov neeg uas noj cov tshuaj paracetamol uas tsis muaj sodium. Qhov kev pheej hmoo ntawm kev tuag kuj siab dua; qhov kev pheej hmoo ntawm ib xyoos yog 7,6% (404 tus neeg tuag) thiab 6,1% (5.510 tus neeg tuag), feem.
Muaj kev pheej hmoo zoo sib xws ntawm cov neeg mob uas tsis muaj ntshav siab. Ntawm cov neeg uas noj cov tshuaj sodium-muaj paracetamol, qhov kev pheej hmoo ntawm CVD ntawm ib xyoos yog 4,4% (105 CVD tus neeg mob) thiab 3,7% (2079 CVD tus neeg mob) ntawm cov neeg uas noj cov tshuaj sodium-free paracetamol. Qhov kev pheej hmoo ntawm kev tuag yog 7,3% (517 tus neeg tuag) thiab 5,9% (5.190 tus neeg tuag), feem.
Xib fwb Zeng tau hais tias "Nws kuj tau pom tias qhov kev pheej hmoo ntawm cov kab mob plawv thiab kev tuag tau nce ntxiv thaum lub sijhawm ntawm sodium-muaj acetaminophen tau txais ntau ntxiv. Qhov kev pheej hmoo ntawm cov kab mob plawv tau nce los ntawm ib feem rau cov neeg mob ntshav siab uas muaj ib qho tshuaj sodium-muaj acetaminophen, thiab ib nrab rau cov neeg mob uas muaj tsib lossis ntau dua cov tshuaj acetaminophen. Peb pom zoo sib xws hauv cov neeg uas tsis muaj ntshav siab. Qhov kev pheej hmoo ntawm kev tuag kuj tseem nce ntxiv los ntawm cov koob tshuaj sodium-muaj acetaminophen hauv cov neeg mob ntshav siab. "
Qhov kev pheej hmoo ntawm kev tuag kuj tseem nce ntxiv nrog kev noj tshuaj ntau ntawm sodium-muaj paracetamol hauv cov neeg mob ntshav siab.
Sodium feem ntau yog siv rau hauv kev npaj lub Hoobkas los txhim kho solubility thiab disintegration. Hauv 2018, 170 tus neeg ntawm 10.000 tus neeg hauv tebchaws Askiv tau siv tshuaj sodium-muaj tshuaj, nrog rau cov poj niam ntau dua.
Nyob rau hauv ib tsab xov xwm nrog rau tsab xov xwm, Alta Schutte, ntawm University of New South Wales thiab George lub koom haum rau Kev Noj Qab Haus Huv Ntiaj Teb, Sydney, Australia, thiab Bruce Neal, ntawm Imperial College London, UK, sau tias tsuas yog hauv UK tau txais 2014 lab. Cov tshuaj muaj cov tshuaj paracetamol hauv xyoo 42, nrog rau ntxiv 200 lab pob muag muag yam tsis tau txais daim ntawv txais nyiaj.
Hauv Spain, xyoo 2015 tag nrho ntawm 32 lab pob khoom ntawm pacetamol tau muag (suav txog 3,8% ntawm tag nrho).
Txheej txheem Summary Archive
"Qhov no sib npaug rau 6.300 tonnes ntawm paracetamol muag txhua xyoo hauv tebchaws Askiv, nrog rau daim duab nce txog 10.000 tonnes hauv Fabkis. Hmoov zoo, tsuas yog ib qho me me ntawm cov tshuaj acetaminophen formulations muaj sodium tab sis, nrog kev nce hauv cov koob npe ntawm 'ceev-ua yeeb yam' thiab 'effervescent' cov tshuaj, cov tshuaj cuam tshuam txog kev tsis zoo ntawm kev noj sodium zoo li nce hauv qhov chaw txo qis ", lawv sau.
Zeng hais tias cov kws kho mob thiab cov neeg mob yuav tsum paub txog cov kev pheej hmoo cuam tshuam nrog sodium-muaj acetaminophen thiab zam kev noj tsis tsim nyog, tshwj xeeb tshaj yog thaum noj tshuaj rau lub sijhawm ntev.
"Cov kws kho mob yuav tsum tau sau tshuaj sodium-dawb acetaminophen rau lawv cov neeg mob kom txo qis kev pheej hmoo ntawm cov kab mob plawv thiab kev tuag. Tib neeg yuav tsum tau saib xyuas tsis yog tsuas yog kev noj ntsev hauv lawv cov zaub mov xwb, tab sis kuj tseem yuav tsum tsis txhob saib xyuas cov ntsev zais cov tshuaj hauv lawv lub txee tshuaj, "nws hais.
Cov xib fwb Schutte thiab Neal hu tau ceev kho qhov kev txiav txim. "Qhov hnyav ntawm cov pov thawj ua rau qhov tsis muaj kev nqis tes ua ntawm cov tshuaj uas muaj sodium tsis tuaj yeem kho tau," lawv sau. "Kev siv ntau yam tshuaj effervescent nyob rau hauv cov pej xeem thiab cov koob tshuaj loj loj ntawm cov dej qab zib uas tuaj yeem haus tsis tau haus vim tias cov neeg siv khoom tsis txaus siab yuav tsum tau ua sai. Kev txhawj xeeb tshwj xeeb yog qhov kev soj ntsuam hauv qee qhov kev tshawb fawb txog li 94% ntawm cov neeg siv cov tshuaj gaseous tus kheej tshuaj nrog npaj OTC. Muaj kev xav tau tam sim rau kev tiv thaiv cov neeg siv khoom tiv thaiv cov kev pheej hmoo no.
Tej zaum qhov ua tau zoo tshaj plaws thiab muaj txiaj ntsig zoo yog qhov yuav tsum tau sau npe ntawm tag nrho cov tshuaj uas muaj cov sodium tseem ceeb nrog rau daim ntawv ceeb toom pem hauv ntej ntawm pob. Cov ntaub ntawv xov xwm uas txhawb nqa pej xeem thiab kev paub txog kev zais sodium hauv cov tshuaj, thiab kev kawm txog kev xav tau kom tsis txhob muaj cov tshuaj effervescent thiab soluble hauv txhua qhov tab sis qhov xwm txheej tseem ceeb, yuav tsum tau txiav txim siab. "
