Ua ʻike ʻia ka noiʻi i paʻi ʻia ma "Nature Communications" i nā hōʻailona e pili ana i ka piʻi nui ʻana o ka metastasis i nā maʻi maʻi maʻi ʻole. ʻO ia ka pheochromocytoma i loaʻa i ʻekolu a ʻewalu mau hihia ma ka miliona mau kānaka i kēlā me kēia makahiki. Hiki ke hoʻohui ʻia kēia mau hōʻailona i nā koina ʻē aʻe a me ka histological no ka hoʻokele lapaʻau pilikino.
ʻO ka Pheochromocytoma kahi maʻi maʻi maʻamau, me ka loaʻa ʻana o ʻekolu a ʻewalu mau hihia ma ka miliona mau kānaka i kēlā me kēia makahiki.
Ua loaʻa ka ʻike me ka uku ʻole no ka noiʻi ʻana o ka mayor e pili ana i nā kumu molekala o kēia maʻi maʻi ʻaʻole i hoʻopaʻa ʻia i nā cell me ka metastatic pheochromocytomas, ʻo ia ka 20% o nā hihia āpau. ʻO ke ola o nā maʻi me ka pheochromocytoma metastatic he 20% a 60% i nā makahiki ʻelima.
"ʻO kekahi o nā paʻakikī o ka hana ʻana me nā maʻi ʻokoʻa ke kiʻi ʻana i ka nui o nā maʻi e hiki ai i nā hopena koʻikoʻi. A ke kū nei kēia haʻawina no ka mea ʻokoʻa ka nui o nā laʻana a mākou i hana ai, "wahi a Mercedes Robledo, kekahi o nā mea noiʻi kākoʻo nāna i alakaʻi i ka hoʻokolokolo.
ʻO ka hapa nui o nā poʻe maʻi me kēia ʻano maʻi maʻi e hoʻomohala ana i nā metastases e hana pēlā i hoʻokahi a ʻelua paha mau makahiki ma hope o ka ʻike ʻana o ka maʻi, akā aia kekahi mau hihia i ulu ai ka metastasis he ʻumi a iwakālua mau makahiki ma hope o ka ʻike mua. Kōkua nā māka molekala hou i nā kauka kūpono e nānā pono i nā poʻe maʻi me ka nui o ka metastasis.
ʻEhia mau genes i komo i loko o kahi paʻa, ʻoi aku ka paʻakikī o kāu aʻo ʻana a ʻoi aku ka paʻakikī o kāu i nā lāʻau lapaʻau maikaʻi.
ʻO kekahi pilikia e pili ana i kēia maʻi kakaʻikahi, ʻaʻole hana mau nā lāʻau lapaʻau, a ʻaʻole ʻike ʻia ke kumu. "Ua hoʻopaʻa ʻia kēia ma 40% -50% o nā hihia - wehewehe ʻo Robledo, kahi mea noiʻi CNIO-, a paʻakikī loa mai kahi ʻano genetic. Ua ʻike ʻia a hiki i ka iwakāluakūmālua mau genes pili i ka maʻi, a ʻelima o ia mau mea i ʻike ʻia i loko o kā mākou hale hana."
ʻOi aku ka nui o nā genes i komo i loko o kahi laka, ʻoi aku ka paʻakikī o kāu noiʻi ʻana a ʻoi aku ka paʻakikī o nā lāʻau lapaʻau maikaʻi. I kēia lā, ua hoʻāʻo ʻia nā ʻano lapaʻau like ʻole, mai ka chemotherapy a i nā lāʻau lapaʻau i hoʻopaʻa ʻia, akā e like me ka wehewehe ʻana e ka luna ʻē aʻe o ka hana, ʻo Bruna Calsina, "ʻaʻole i ʻike ʻia he priori e hiki ai i nā mea maʻi ke pane i kekahi lapaʻau a i ʻole kekahi."
No kēia kumu, ʻo kahi ʻāpana ʻē aʻe o ka noiʻi ʻana i ka ʻimi ʻana i nā māka e hiki ai ke hana pilikino i ka mālama ʻana. Ua ʻike ʻia ka noiʻi i kahi hui o nā maʻi pheochromocytoma i hiki ke pōmaikaʻi mai ka mālama ʻana i ka immunotherapy
